EF-S lenses are designed for Canon DSLR cameras with APS-C sensors, while EF-M lenses are specifically for Canon mirrorless cameras with APS-C sensors. EF-S lenses are not compatible with Canon mirrorless cameras, and vice versa. In terms of performance, EF-S lenses may offer faster autofocus and better image quality on DSLR cameras, while EF-M lenses are typically more compact and lightweight for mirrorless cameras.
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