Can you tell the difference between Oxycontin and methadone in a drug test?

Yes they can tell the difference in Methadone and hydrocodone Methadone has to be tested separately in a test it is not on the 5 panel test. Hydrocodone however is an opiate and will show up as an opiate. Methadone is a synthetic opiate and is in a class all of its own. Methadone tricks the brain into thinking that its still has heroin/opiates in the body it works the same in the brain. So to answer your question they would have to test separate for methadone. It is two totally different drug classes.

I personally don't think on a dipstick they can. Methadone is still an opiate. I took it for years with loracet and never saw the dr tell a difference. Sorry to tell ya.