Use of quinine sulfate

Quinine sulfate is primarily used to treat malaria, particularly in cases caused by Plasmodium falciparum, the most severe form of the disease. It can also be prescribed off-label for leg cramps and restless leg syndrome, although these uses are less common due to potential side effects. Quinine acts as an antimalarial agent by interfering with the parasite's ability to digest hemoglobin in red blood cells. However, its use has declined with the availability of more effective and safer antimalarial medications.