The condition of skeletal muscle fatigue can be best explained by?

Skeletal muscle fatigue is primarily attributed to a combination of factors, including the depletion of energy substrates (like ATP and glycogen), the accumulation of metabolic byproducts (such as lactic acid), and impaired calcium handling within muscle fibers. Additionally, changes in the nervous system's ability to stimulate muscles can contribute to fatigue. These factors together hinder muscle contraction efficiency and reduce overall performance during prolonged or intense physical activity.