Who is Mona Lisa supposed to be a painting of?

A Florentine lady.

Mona Lisa is a famous painting of a sitting woman by Leonardo Da Vinci. Mona Lisa is named for Lisa del Giocondo, a member of the Gherardini family of Florence and Tuscany, Italy and the wife fo weatthy Florentine silk merchang Francesco del Giocondo. The pinting was commissioned for their new home and to celebrate the birth of their second son, Andrea.