NEVER!Coadministration with fluoxetine may significantly increase the plasma concentrations of some tricyclic antidepressants (TCAs) especially nortriptyline.
The combination of fluoxetine (or any other selective serotonin reuptake inhibitor) and a TCA such as nortriptyline may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5HT1A receptors.
BTW, I once had serotonin syndrome; it was no picnic! I nearly died.
Copyright © 2026 eLLeNow.com All Rights Reserved.