ibuprofen generally has a half-life of about 2 to 4 hours in healthy adults, which means it takes that long for half of the drug to be eliminated from the body. It typically takes about 5 half-lives for a drug to be considered mostly cleared, so ibuprofen can take around 10 to 20 hours to be eliminated after the last dose. However, factors like dosage, frequency of use, and individual metabolism can influence this timeline.
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