How can simvastatin be used to treat hypercholesterolemia?

Simvastatin is a statin. It is a HMG-CoA reductase inhibitor. It leads to less cholesterol being produced. Low cholesterol will activate the SREBP2 protein. The protein is a transcription factor causes LDL receptors to be upregulated. Low cholesterol also results in less VLDL being synthesised. The statins also inhibit ApoB from being produced so less VLDL gets produced.