What type of neuroglia is in Tay-Sachs syndrome?

Tay-Sachs syndrome primarily affects neurons and is associated with a deficiency of the enzyme hexosaminidase A, leading to the accumulation of GM2 gangliOSides in nerve cells. While the condition primarily impacts neurons, astrocytes, a type of neuroglia, may also be involved as they respond to neuronal damage and inflammation. However, the main pathology of Tay-Sachs is centered on the neural cells rather than a specific alteration of neuroglia themselves.