Why would changing the plugs and wires in a 92 s10 4x4 cause it not to crank?

If by "not to crank" you mean the engine won't turn over, then the problem lies with the battery and/or starter cables. If you mean "not to start", then you need to ensure the plugs are gapped correctly (new plugs are not always pre-gapped) and that the wires are seated and routed correctly. Inspect the area near the plugs and wiring in case you may have disconnected something while changing them out.