To bleed the air out of the fuel system on a 2005 Ford F250 Diesel 6.0, first ensure the vehicle is off and the fuel tank is filled. Locate the Schrader valve on the fuel filter housing and use a flathead screwdriver to press it, releasing any trapped air. Then, turn the ignition key to the "On" position (without starting the engine) for about 30 seconds to allow the fuel pump to pressurize the system, and repeat this process a few times. Finally, start the engine and check for any leaks or irregularities.
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