How do leopards respond to danger?

They will almost always run, especially when confronted by humans. Leopards are the most intelligent cat, so it will most likely be gone before you even know it's there. If cornered it will crouch down, lay its ears flat, snarl, hiss, and bare its claws and teeth to try and scare away the impending attacker. There is little chance of a human fighting off a leopard with their bare hands.