Why does tolerance work in some psychedelics?

Tolerance to psychedelics occurs due to neuroadaptive mechanisms in the brain, where repeated use can lead to desensitization of receptor systems, particularly serotonin receptors like the 5-HT2A receptor. This desensitization reduces the drug's effects over time, requiring higher doses to achieve the same experience. Additionally, the body's physiological processes may adapt to the presence of the substance, further contributing to tolerance. However, the rate and extent of tolerance can vary significantly between different psychedelics.