What transmitters likely contributes to the immediate reward caused by narcotic use?

The immediate reward from narcotic use is primarily attributed to the release of neurotransmitters such as dopamine, particularly in the brain's reward pathway, including the ventral tegmental area and nucleus accumbens. Opioids bind to specific receptors (mu-opioid receptors) that enhance dopamine release, producing feelings of euphoria and pleasure. Additionally, other neurotransmitters like endorphins may also play a role in modulating pain and stress, further contributing to the rewarding experience. Together, these transmitters create a strong reinforcing effect that can lead to addiction.