Can an antibiotic cause swelling

i think it is the body/bacteria. I had blood poisioning once and while in the hospital and on antibiotics a had spontanious and random swelling. My lip got big and ichy and on different places on my skin would develop and raised red blotch. i was given an over the counter for the swelling and the antibiotic was changed. Though this was the highlight of the swelling, leading up to my time in the hospital i noticed the same on my ass. It appeared and was gone quickly. It might have something to do with the body resisting it.