What is an example when the outbreak of a disease such as the bubonic plague that kills large numbers of people in a city?

An example of a disease outbreak is the Bubonic Plague, which struck Europe in the 14th century, particularly in cities like Florence. The plague, carried by fleas on rats, led to the deaths of an estimated one-third of the population, causing widespread panic and social upheaval. The high mortality rate resulted in labor shortages, economic decline, and changes in social structures, profoundly impacting the course of European history.