How long does 800 mg Motrin stay in your system?

ibuprofen, the active ingredient in Motrin, typically has a half-life of about 2 to 4 hours in healthy individuals. This means that it takes this amount of time for half of the drug to be eliminated from the body. Generally, it can take about 24 hours for the drug to be mostly cleared from your system after a dose of 800 mg, depending on individual metabolism and other factors. However, traces may remain for longer periods, especially with repeated use.