Major cholera epidemics include the first pandemic, which began in 1817 and spread from India to Southeast Asia, the Middle East, and parts of Europe, causing widespread fatalities. The second pandemic (1829-1851) is often considered the deadliest, significantly impacting Europe and North America. The third pandemic (1852-1860) was particularly severe in England, with London experiencing a major outbreak. Subsequent pandemics continued to emerge, notably the seventh pandemic starting in 1961, which originated in Indonesia and remains a concern today.
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