What is 'Qu'est-ce que c'est mon ami' when translated from French to English?

"What is it, my friend?" is one literal English equivalent of the French present indicative question Qu'est-ce que c'est, mon ami? The pronunciation of the Words -- which more loosely translate as "What's bothering you, my friend?" -- will be "keh-skuh sey mo-na-mee" in French.