Can Adderall be taken with Tramadol?

Yes, in some cases. Adderall contains amphetamine which is a central nervous system stimulant. Tramadol is an opioid used to treat pain. Both medications are known to lower the seizure threshold; combining these two drugs could result in seizures. Consult your physician or medical professional if this combination is safe for you. If your doctor prescribed this combination, he or she has decided that the benefits outweigh the potential risks.