What route runs parallel to route 81?

Route 81, which primarily refers to Interstate 81 (I-81) in the United States, runs parallel to U.S. Route 11. Both routes travel through the same general regions, particularly in the eastern United States, providing similar north-south connections. While I-81 is a major interstate highway designed for faster travel, U.S. Route 11 is a more local road that often passes through towns and cities along its path.