What is the shortest route from Humble TX to Nashville TN?

The shortest route from Humble, TX, to Nashville, TN, typically involves taking I-45 N from Humble to connect with I-10 E. Then, you would merge onto I-40 E, which leads directly to Nashville. The trip covers approximately 600 miles and usually takes around 8-9 hours, depending on traffic and road conditions. Always check a GPS or mapping service for the most current route and conditions before you travel.