How soon can you feel the side effects of Zoloft?

Side effects of Zoloft (sertraline) can begin to manifest within the first week of treatment, although it may take several weeks for the full effects to be experienced. Common early side effects include nausea, insomnia, and fatigue. However, individual responses can vary, and some people may not experience side effects at all or may have a delayed onset. Always consult a healthcare professional regarding any concerns about medication.