What is the worst curse that could be put on you?

The worst curse that could be placed on someone might be an eternal state of isolation, where they are surrounded by people yet feel completely disconnected and unable to communicate. This could lead to profound loneliness and despair, stripping away the ability to form meaningful relationships or find joy in life. Such a curse would not only affect one's mental health but also diminish the very essence of what it means to be human—connection and belonging.