Is it safe to take hydrocodone and xanax at the same time?

YES, it can be safe to take tramadol, Xanax (alprazolam), and hydrocodone at one time as long as they are used under medical supervision.

You have to be very carefully taking benzodiazepines (Xanax, Valium, Ativan etc.) with opioids (hydrocodone, oxycodone, morphine etc.). Benzodiazepines and opioids are commonly used together for legitamite reasons however abuse of multiple drugs increases risk of serious, even life threatening side effects. Large numbers of deaths due to an overdose are attributed to polysubstance abuse, particularly opioids and benzodiazepines. When the drugs are prescribed and used appropriately they are typically safe.