Is it safe to take Tylenol for a migraine and NyQuil for cold relief?

Depends on how much you are taking. Nyquil has aceteminephen (sp?)in it too so you should see what the total dose is that you have taken. The Tylenol bottle should have a dosage chart on it with the 'maximum dose' you should ingest. Too much acetaminephen can damage your kidneys and/or liver. If you drink alcohol be sure to read the warning on both medicine packages. For sore throat pain I have better relief with Ibuprophen (Advil