The project that left Michelangelo partially crippled was the construction of the dome of St. Peter's Basilica in Vatican City. While working on this monumental project, he suffered from various physical ailments, including frequent bouts of illness and strain from the demanding work. The intense labor and scaffolding involved in the dome's construction took a toll on his body, leading to lasting physical issues. Despite these challenges, he successfully completed the dome, which remains an architectural marvel today.
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