Is it safe to take 100 mg of prednisone in one sitting?

Taking 100 mg of prednisone in one sitting can be safe for certain individuals under medical supervision, particularly for short-term treatment of severe conditions. However, such a high dose can lead to significant side effects, including increased blood sugar, mood changes, and potential complications with the immune system. It's crucial to follow a healthcare provider's guidance regarding dosage and duration to mitigate risks. Always consult a doctor before making any changes to medication regimens.