Should Tylenol 3 be taken on full stomach?

Tylenol 3, which contains acetaminophen and codeine, can be taken with or without food, but taking it on a full stomach may help reduce the risk of gastrointestinal side effects, such as nausea. If you have a sensitive stomach or are prone to upset stomachs, it’s generally advisable to take it with food. Always follow your healthcare provider’s instructions regarding medication use.