What causes elevated IgG subclasses?

Elevated IgG subclasses can be caused by chronic infections, autoimmune diseases, and certain inflammatory conditions, as the immune system produces more antibodies in response to ongoing stimuli. Additionally, genetic factors and some malignancies, such as multiple myeloma, may also contribute to increased levels of specific IgG subclasses. In some cases, elevated levels may indicate an abnormal immune response or dysregulation. Testing and diagnosis should be guided by a healthcare professional to determine the underlying cause.