What does PMA mean in medicine?

In medicine, PMA stands for "Progressive Multifocal Leukoencephalopathy," which is a rare and serious brain infection caused by the John Cunningham virus (JCV). It primarily affects individuals with weakened immune systems, such as those with HIV/AIDS or those undergoing immunosuppressive therapies. PMA is characterized by the progressive degeneration of the white matter in the brain, leading to neurological symptoms like cognitive decline, motor dysfunction, and loss of coordination. Early diagnosis and management of underlying immunosuppression are crucial for improving outcomes.