How many people with sickle cell die each year?

Approximately 100,000 people in the United States are affected by sickle cell disease, and while advancements in treatment have improved life expectancy, it is estimated that around 1,000 to 2,000 individuals die from the disease each year in the U.S. Globally, the World Health Organization estimates that sickle cell disease contributes to over 200,000 deaths annually, particularly in regions like sub-Saharan Africa where access to healthcare may be limited. The exact numbers can vary based on healthcare access, disease management, and other factors.