Which are the most toughest cancers to cure and why?

The toughest cancers to cure include pancreatic, brain (especially glioblastoma), and ovarian cancers. These cancers are often diagnosed at advanced stages due to vague symptoms, making early detection challenging. Additionally, their aggressive nature and ability to metastasize rapidly contribute to poorer prognoses. Moreover, their unique biological characteristics can render them resistant to conventional treatments, complicating effective management.