That's an extraordinarily broad question and doesn't have a simple answer. In the US alone there have been about 20 different denominations of coins minted at 8 separate Mints over a period of 215 years so there's thousands of possible coins to look for, AND you have to decide on what the term "A LOT(*)" means!
As a brief overview, certainly any silver or gold coins will be worth much more than their face value today. As of 10/2010, 90% silver coins are worth at least 10 times their face value as scrap and gold coins are worth about 150 times face.
That said, many older (early 20th century and before) coins can be worth even more to a collector or dealer so selling them to one of those "we buy gold" places is a good way to be low-balled. Here are just a few of the hundreds and hundreds of older coins that are worth quite a bit:
Lincoln cents
1955 with a doubled image
1914-D and 1909-S VDB
Nickels
1912 Liberty head with a D or S mint mark
1937-D with a 3-legged buffalo
Dimes
1916-D Mercury head
1942 with 1941 showing underneath
Quarters
1916 Standing Liberty
1932-D
1932-S
Half dollars
1921, 1921-D
1916-S
Silver dollars
1928 no mint mark
and so on.
(*) Please be careful of this expression. A LOT is two Words. There's no such thing as "alot", just "a lot" and "allot", and they're not related at all!!
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