How long to cook manicotti in oven?

To cook manicotti in the oven, preheat it to 375°F (190°C). Bake the stuffed manicotti for about 25 to 30 minutes, covered with foil, then remove the foil and bake for an additional 10 to 15 minutes until the cheese is bubbly and golden. Always check that the internal temperature reaches at least 165°F (74°C) for safe consumption.