Can House Spiders harm you

Not usually. There are a few dangerous kinds, like the Black Widow spider. However, it is very rare that anyone actually finds one of these. If you want to be extra-careful, you could look up "poisonous Spiders" on a search engine and look them over, so you might recognize a dangerous one, if you see it. However, this should not be needed. It is highly unlikely that you will actually come across anything to be concerned about.