Will a suffix change the meaning of the medical term?

Yes. Here are some examples.

Melanoma -oma = tumor/growth (tumor of the melanocyte)

Splenectomy -ectomy = remove (procedure to cut out the spleen)

Dermoplasty -plasty = repair (procedure to repair the skin)

Cardiography -graphy = write + process (X-ray of the heart)

Biopsy -opsy = to see + procedure (looking at a sample of tissue)