What is the meaning of HRZE an antituberculosis drug?

They're the abbreviations for the 4 most common antimicrobial agents used in the treatment of active or (to some degree) latent TB.

H = isoniazid

R = rifampin

Z = pyrazinamide

E = ethambutol

If everything goes to plan, a positive TB culture earns you 2 months of HRZE therapy with a continuation of just the rifampin and isoniazid for another 4.