How long do you cook a 4.5 lb brisket?

For a 4.5 lb brisket, you should cook it for approximately 1 to 1.5 hours per pound at a low temperature, typically around 225°F to 250°F (107°C to 121°C). This means you'll be looking at a total cooking time of about 4.5 to 6.5 hours. It's important to use a meat thermometer to check for an internal temperature of around 195°F to 205°F (90°C to 96°C) for optimal tenderness. Additionally, allowing the brisket to rest for at least 30 minutes after cooking will enhance its flavor and juiciness.