Can you take Solpadeine with Concerta?

Codeine is OK to take while on concerta, however, be careful with a codeine cough syrup. Some codeine cough syrup also contains Pseudophedrine Hydrochloride, a decongestant. Pseudophedrine Hydrochloride will react with concerta and cause nervousness, shakiness, increased heart rate, and anxiety. The reason being is that concerta is a Central Nervous System (CNS) stimulant and so is Pseudophedrine Hydrochloride, causing a "double whammy" to your CNS. It depends from person to person on if the codeine will cause drowsiness or wakeuflness.