That's not a good sign, particularly if the itching is around the patch edges, and worse if it's the entire patch area.
Itching usually indicates either an allergic reaction to the patch adhesive material, or the patch material itself. If the entire skin area under the patch is itching, you likely have an allergy to the gel or the Fentanyl itself.
The other possibility is an irritant on the skin prior to patch application. This is common if you've cleaned the area with alcohol and not rinsed it well with water, or you've used some type of other skin product before putting on the patch. Shaving the area and then immediately putting it on can cause irritation as well if it's not rinsed well.
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