What present-day individuals have overcome obstacles to excel at something?

I know Oprah and Jillian Michaels have overcome some weight obstacles. They struggled with they're weight, and they lost it. Jillian Michaels started Martial Arts when she was about 14, and that's how she lost the weight...I don't know when Oprah overcame her weight.

There's MANY more people who have overcome more obstacles than weight, but these r the people that came off the top of my head.