Rheumatoid Arthritis (RA) is a complex autoimmune disease influenced by multiple genetic factors rather than a single mutation on specific chromosomes. However, several genetic loci associated with RA have been identified, particularly on chromosome 6, which contains the HLA (human leukocyte antigen) genes. Other chromosomes, such as 1, 2, 3, 5, and 9, also harbor genes linked to RA susceptibility. The interplay of these genetic factors, along with environmental triggers, contributes to the development of the disease.
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