Yes, long-term use of Nexium (esomeprazole), a proton pump inhibitor, has been associated with an increased risk of kidney problems, including acute interstitial nephritis and chronic kidney disease. Some studies suggest that prolonged use may lead to a decline in kidney function. It's important for patients to discuss any concerns with their healthcare provider, especially if they are on long-term therapy. Regular monitoring of kidney function may be recommended for those taking Nexium over extended periods.
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