The original Shamu died in SeaWorld Flordia after 6 years in captivity after being taken violently from his pod with his mother (who died succumbing to the wounds of the harpoon used to catch her) at a young age.
I don't think anyone really knows what he died of but a lot of orcas do not do well once they have been taken from the wild, they are under a lot of stress as the environment is drastically different, they are potentially exposed to chemicals in the water and become more susceptible to infections and they need to adjust to a different diet. In a lot of cases, cause of death is still unknown or put down as 'stress' or 'stress related'. Apart from 'unknown' the most common cause of death in captivity is bacterial pneumonia and it is not unlikely that this is what the original Shamu died of as well.
Causes of death in some of SeaWorld's other Shamus in the last 10 years:
2008: Halyn (2.5): unknown/ not publicized
2007: Taku (14): unknown/ not publicized, probably infection as he was put on antibiotics prior to his death.
2005: Splash (15.5): complications with a tooth infection
2001: Bjossa (21): chronic lung infection
2001: Haida 2 (19) :brain abcess
1999: Katerina (10.5): infection of some sort
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