If a horse and a donkey are bred their offspring is a hybrid known as a mule. is a disadvantage of many hybrid animals including the mule?

A disadvantage of many hybrid animals, including mules, is that they are often sterile and cannot reproduce. This sterility arises from the differing number of chromosomes in the parent species, which leads to complications during meiOSis. As a result, while mules can be strong and useful animals, their inability to reproduce limits their population and potential for genetic diversity.