To reprogram a keyless remote for a Lexus IS 300, first, sit in the driver's seat and close all doors. Insert the key into the ignition and turn it to the "On" position without starting the engine, then turn it back to "Off" and remove the key. Within 5 seconds, insert the key back into the ignition and turn it to "On" again, then press and hold the "Lock" button on the remote until the doors lock and unlock, indicating successful programming. Repeat for additional remotes if needed, then turn the ignition to "Off" to complete the process.
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