Definition of mulliken barker reaction

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2026-02-07 20:10

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The Mulliken-Barker reaction is a chemical transformation that involves the reaction of an aromatic compound with an alkyl halide in the presence of a strong base to form an alkylated aromatic compound. This reaction typically employs a base such as sodium hydride or potassium tert-butoxide to deprotonate the aromatic compound, facilitating the nucleophilic attack on the alkyl halide. It is notable for its ability to produce alkylated products under mild conditions, making it useful in organic synthesis.

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