Can you breed small female cockapoo with medium cockapoo?

Yes, you can breed a small female cockapoo with a medium cockapoo. However, it's essential to consider the size difference and ensure that the smaller female is healthy enough to carry and deliver the puppies safely. Breeding should always be approached responsibly, considering the health and temperament of both parent dogs to produce healthy offspring. Consulting with a veterinarian or a professional breeder is advisable before proceeding.