How does the body fight against smallpox?

The body fights against smallpox through the immune response, primarily by producing antibodies and activating T-cells. When exposed to the smallpox virus, the immune system recognizes it as foreign and generates specific antibodies that neutralize the virus. Additionally, cytotoxic T-cells target and destroy infected cells. Vaccination also plays a crucial role, as it primes the immune system to recognize and respond quickly to the virus, providing immunity without causing the disease.